|James Fitzpatrick, Ph.D., is the inaugural scientific director of the Washington University Center for Cellular Imaging (WUCCI) and an associate professor of Neuroscience and Cell Biology and Physiology in the School of Medicine. Fitzpatrick completed his doctoral research in chemical physics and laser spectroscopy at the University of Bristol in the United Kingdom and completed further post-doctoral training at the University of Pittsburgh and Carnegie Mellon University. |
While at Carnegie Mellon, he served as a principal team member of the National Technology Center for Networks and Pathways whose mandate was to develop fluorescent biosensors along with new imaging and informatics approaches to study signaling in living cells and tissues. There he worked on the development and validation of both quantum dot semiconductor nanocrystals for lymphatic tracking and tumor imaging in vivo and genetically targeted fluorogen activating protein (FAP) fluorescent probes for cellular imaging and live-cell superresolution nanoscopy.
Upon leaving Carnegie Mellon, he moved to the Salk Institute for Biological Studies to build the Waitt Advanced Biophotonics Center, a cutting-edge microscopy and imaging center. There he leveraged his undergraduate and doctoral training in chemistry and physics and his post-doctoral training in microscopic imaging and fluorescence detection methods under Alan Waggoner, the inventor of the CyDye™ fluorescent probe technologies, to design and implement microscopic and macroscopic imaging based assays.
At Washington University in St. Louis, his primary research interests lie in the integration and application of multi-scale optical and charged-particle imaging technologies. Specifically, the biological applications of ion microscopy, the development of correlative light and electron microscopy approaches, and new computational tools to visualize and manipulate large-scale multidimensional data sets. All with the aim to study the structure and function of biological systems from in vitro cell cultures to developing organisms.